Events

• January 19 – Treaty of Barcelona: Charles VIII of France returns Cerdagne and Roussillon to Ferdinand of Aragon.

• April – Christopher Columbus returns to Spain from his first voyage of discovery.

• May 4 – In the papal bull Inter caetera, Pope Alexander VI decrees that all lands discovered west of the Azores are Spanish.

• August 19 – Maximilian I succeeds his father, Frederick III, as Holy Roman Emperor.

• September 9 – Battle of Krbava field was fought between the Kingdom of Croatia and Ottoman forces in southern Croatia.

• September 29 – Christopher Columbus leaves Cadiz on his second voyage of exploration.

• November 19 – Columbus lands on the coast of the island of Borinquen, which he renames San Juan (today, Puerto Rico).

Births

• March 15 – Anne de Montmorency, Constable of France (d. 1567)

• June 5 – Justus Jonas, German Protestant reformer (d. 1555)

• September 28 – Agnolo Firenzuola, Italian poet (d. c. 1545)

• October 14 – Shimazu Tadayoshi, Japanese warlord (d. 1568)

• November 11 (or December 17 – Paracelsus, Swiss physician and scientist (d. 1541)

• November 12 – Bartolommeo Bandinelli, Italian artist and sculptor (d. 1560)

• date unknown

• *Simon Grynaeus, German scholar and theologian (d. 1541)

• *Takeda Nobutora, Japanese warlord (d. 1573)

• *Matsudaira Shigeyoshi, Japanese general (d. 1580)

• probable

• *Jean du Bellay, French cardinal and diplomat (d. 1560)

• *Robert Maxwell, 4th Lord Maxwell, Scottish statesman (d. 1546)

Deaths

• May 10 – Colin Campbell, 1st Earl of Argyll, Scottish politician (b. c. 1433)

• June 14 – Ermolao Barbaro, Italian scholar (b. 1454)

• August 19 – Frederick III, Holy Roman Emperor (b. 1415)

• September 9 – Mirko Derenčin, Croatian leader

• November – Martin Alonzo Pinzón, Spanish navigator and explorer (b. c. 1441)

• November 6 – Andrey Bolshoy, Russian prince (b. 1446)

• *James Blount, English soldier

• *James Douglas, 1st Earl of Morton

• *Pietro Antonio Solari, Italian architect (b. 1450)

• *Tupac Inca Yupanqui, Inca ruler of Tahuantinsuyu